A futuristic laboratory assigns different tasks to its various residents, who then have their memories erased upon the completion of their assignments.
The show follows an organization that employs mind-wiped humans known as Dolls who are implanted with false memories and skills for various missions and tasks.
When they are not 'at work' they are living in a real life Dollhouse which gives the show the name.
One of those mind-wiped humans, a young woman named Echo, is slowly starting to become aware of herself and what's going on.
All the while somebody on the outside is trying to bring the Dollhouse down while getting closer to Echo - possibly not aware that she is one of the Dolls he is after.
- Eliza Dushku
- Harry Lennix
- Fran Kranz
Created by: Joss Whedon